Selected Publications:

•  Wang XY, Xu YM, Lau ATY. Proteogenomics in Cancer: Then and Now. J Proteome Res. 2023 Oct 6;22(10):3103-3122. doi: 10.1021/acs.jproteome.3c00196. Epub 2023 Sep 19. PMID: 37725793.

•  Xu YM, Lee MH, Wong CM, Lau ATY. Editorial: Characterizing the uncharacterized human proteins. Front Genet. 2023 May 4;14:1203691. doi: 10.3389/fgene.2023.1203691. PMID: 37234873; PMCID: PMC10206516.

•  Wu YY, Xu YM, Lau ATY. Epigenetic effects of herbal medicine. Clin Epigenetics. 2023 May 13;15(1):85. doi: 10.1186/s13148-023-01481-1. PMID: 37179342; PMCID: PMC10183144.

•  Wu YY, Wu GQ, Cai NL, Xu YM, Lau ATY. Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability. Int J Mol Sci. 2023 Mar 23;24(7):6067. doi: 10.3390/ijms24076067. PMID: 37047039; PMCID: PMC10093921.

•  Yu FY, Xu Q, Zhao XY, Mo HY, Zhong QH, Luo L, Lau ATY, Xu YM. The Atypical MAP Kinase MAPK15 Is Required for Lung Adenocarcinoma Metastasis via Its Interaction with NF-κB p50 Subunit and Transcriptional Regulation of Prostaglandin E2 Receptor EP3 Subtype. Cancers (Basel). 2023 Feb 22;15(5):1398. doi: 10.3390/cancers15051398. PMID: 36900191; PMCID: PMC10000388.

• Ding Q, Xu YM, Lau ATY. The Epigenetic Effects of Coffee. Molecules. 2023 Feb 13;28(4):1770.PMID: 36838754.

• Yu FY, Xu Q, Zhao XY, Mo HY, Zhong QH, Luo L, Lau ATY, Xu YM. The Atypical MAP Kinase MAPK15 Is Required for Lung Adenocarcinoma Metastasis via Its Interaction with NF-κB p50 Subunit and Transcriptional Regulation of Prostaglandin E2 Receptor EP3 Subtype. Cancers (Basel). 2023 Feb 22;15(5):1398. PMID: 36900191.

• Wei QY, Lau ATY, Mo HY, Zhong QH, Zhao XY, Yu FY, Han J, Wu YY, Xu YM. Effects of CYP3A43 Expression on Cell Proliferation and Migration of Lung Adenocarcinoma and Its Clinical Significance. Int J Mol Sci. 2022 Dec 21;24(1):113. PMID: 36613552.

• Wu DD, Dai LJ, Tan HW, Zhao XY, Wei QY, Zhong QH, Ji YC, Yin XH, Yu FY, Jin DY, Li SQ, Lau ATY, Xu YM. Transcriptional upregulation of MAPK15 by NF-κB signaling boosts the efficacy of combination therapy with cisplatin and TNF-α. iScience. 2022 Oct 28;25(12):105459. PMID: 36425765.

• Chen XX, Xu YM, Lau ATY. Metabolic effects of long-term cadmium exposure: an overview. Environ Sci Pollut Res Int. 2022, 29(60). PMID: 36367641.

• Zhong QH, Zha SW, Lau ATY, Xu YM. Recent knowledge of NFATc4 in oncogenesis and cancer prognosis. Cancer Cell Int. 2022 Jun 13;22(1):212. PMID: 35698138.

• Wu JX, Lau ATY, Xu YM. Indoor Secondary Pollutants Cannot Be Ignored: Third-Hand Smoke. Toxics. 2022;10(7):363. PMID: 35878269.

• Mo HY, Wei QY, Zhong QH, Zhao XY, Guo D, Han J, Noracharttiyapot W, Visser L, van den Berg A, Xu YM, Lau ATY. Cytochrome P450 27C1 Level Dictates Lung Cancer Tumorigenicity and Sensitivity towards Multiple Anticancer Agents and Its Potential Interplay with the IGF-1R/Akt/p53 Signaling Pathway. Int J Mol Sci. 2022 Jul 16;23(14):7853. PMID: 35887201.

• Chen XL, Xu YM, Lau ATY. Toxic metals in the regulation of epithelial-mesenchymal plasticity: demons or angels? Cancer Cell Int. 2022 Jul 27;22(1):237. PMID: 35897065

• Tan HW, Xu YM, Liang ZL, Cai NL, Wu YY, Lau ATY. Single-gene knockout-coupled omics analysis identifies C9orf85 and CXorf38 as two uncharacterized human proteins associated with ZIP8 malfunction. Front Mol Biosci. 2022, 9: 991308. PMID: 36330220.

• Yin XH, Xu YM, Lau ATY. Nanoparticles: Excellent Materials Yet Dangerous When They Become Airborne. Toxics. 2022, 10(2):50.PMID: 35202237.

• Yu FY, Xu Q, Wei QY, Mo HY, Zhong QH, Zhao XY, Lau ATY, Xu YM. ACC2 is under-expressed in lung adenocarcinoma and predicts poor clinical outcomes. J Cancer Res Clin Oncol. 2022, 148:3145–3162. PMID: 35066671.

• Wu YY, Xu YM, Lau ATY. Anti-Cancer and Medicinal Potentials of Moringa Isothiocyanate. Molecules. 2021, 26(24):7512. PMID: 34946594.

• Tan HW, Xu YM, Lau ATY. Human bronchial-pulmonary proteomics in coronavirus disease 2019 (COVID-19) pandemic: applications and implications. Expert Rev Proteomics. 2021: 1-14. PMID: 34812694 .

• Liang ZL, Tan HW, Wu JY, Chen XL, Wang XY, Xu YM, Lau ATY. The Impact of ZIP8 Disease-Associated Variants G38R, C113S, G204C, and S335T on Selenium and Cadmium Accumulations: The First Characterization. Int J Mol Sci. 2021, 22(21). PMID: 34768831.

• Yan R, Chen XL, Xu YM, Lau ATY. Epimutational effects of electronic cigarettes. Environ Sci Pollut Res Int. 2021. PMID: 33655478 .

• Tan HW, Xu YM, Qin SH, Chen GF, Lau ATY. Epigenetic regulation of angiogenesis in lung cancer. J Cell Physiol. 2020 Oct 19. PMID: 33078404.

• Wu DD, Xu YM, Chen DJ, Liang ZL, Chen XL, Hylkema MN, Rots MG, Li SQ, Lau ATY. Ubiquitin carboxyl-terminal hydrolase isozyme L1/UCHL1 suppresses epithelial-mesenchymal transition and is under-expressed in cadmium-transformed human bronchial epithelial cells. Cell Biol Toxicol. 2020 Oct 10. PMID: 33040242.

• Wei QY, Xu YM, Lau ATY. Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies. Cancers. 2020, 12. PMID: 32998391.

• Kong AN, Lau ATY, Brunetti L. Hot Topic Commentary on COVID-19. Curr Pharmacol Rep . 2020, 1-3. PMID: 32395419.

• Yao Y, Tan HW, Liang ZL, Wu GQ, Xu YM, Lau ATY. The Impact of Coilin Nonsynonymous SNP Variants E121K and V145I on Cell Growth and Cajal Body Formation: The First Characterization. Genes. 2020, 11, 895. PMID: 32764415.

• Tan HW, Xu YM, Lau ATY. Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection. Rev Med Virol. 2020 Jun 30; e2122. PMID: 32602627.

• Wu GQ, Xu YM, Lau ATY. Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease. Cancer Cell Int. 2020 Apr 29;20:142. doi: 10.1186/s12935-020-01226-7. eCollection 2020. PMID: 32368188.

• Zhao XY, Wang XY, Wei QY, Xu YM, Lau ATY. Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy. Cells. 2020 Apr 18;9(4):1012. PMID: 32325691.

• Qin SH, Lau ATY, Liang ZL, Tan HW, Ji YC, Zhong QH, Zhao XY, Xu YM. Resveratrol Promotes Tumor Microvessel Growth via Endoglin and Extracellular Signal-Regulated Kinase Signaling Pathway and Enhances the Anticancer Efficacy of Gemcitabine against Lung Cancer. Cancers. 2020 Apr 15;12(4):974. PMID: 32326402.

• Xu YM, Tan HW, Zheng W, Liang ZL, Yu FY, Wu DD, Yao Y, Zhong QH, Yan R, Lau ATY. Cadmium telluride quantum dot-exposed human bronchial epithelial cells: a further study of the cellular response by proteomics. Toxicol Res. 2019;8(6):994-1001. doi:10.1039/C9TX00126C

• Wei QY, He KM, Chen JL, Xu YM , Lau ATY. Phytofabrication of Nanoparticles as Novel Drugs for Anticancer Applications. Molecules. 2019; 24(23):4246. doi:10.3390/molecules24234246. PMID: 31766544.

• Tan HW, Liang ZL, Yao Y, Wu DD, Mo HY, Gu J, Chiu JF, Xu YM, Lau ATY. Lasting DNA Damage and Aberrant DNA Repair Gene Expression Profile are Associated with Post-Chronic Cadmium Exposure in Human Bronchial Epithelial Cells. Cells. 2019 Aug 6;8(8):842. doi: 10.3390/cells8080842. PMID: 31390735.

• Lau ATY, Yu FY, Xu YM. Epigenetic Effects of Essential Fatty Acids. Curr Pharmacol Rep. 2019; 5(1):68–78. doi:10.1007/s40495-019-00166-9.

• Tan HW, Mo HY, Lau ATY, Xu YM. Selenium Species: Current Status and Potentials in Cancer Prevention and Therapy. Int J Mol Sci. 2018 Dec 25;20(1). doi: 10.3390/ijms20010075. PMID: 30585189.

• Huang SJ, Xu YM, Lau ATY. Epigenetic Effects of the 13 Vitamins. Curr Pharmacol Rep. 2018; 4(6):453–467. doi: 10.1007/s40495-018-0161-2.

• Lau ATY, Xu YM. Regulation of human mitogen-activated protein kinase 15 (extracellular signal-regulated kinase 7/8) and its function: A recent update. J Cell Physiol. 2018 Aug 2. doi: 10.1002/jcp.27053. PMID: 30070699.

• Liang ZL, Wu DD, Yao Y, Yu FY, Yang L, Tan HW, Hylkema MN, Rots MG, Xu YM, Lau ATY. Epiproteome profiling of cadmium-transformed human bronchial epithelial cells by quantitative histone post-translational modification-enzyme-linked immunosorbent assay. J Appl Toxicol. 2018 Feb 9. doi: 10.1002/jat.3597. PMID: 29423916.

• Tan HW, Xu YM, Wu DD, Lau ATY. Recent insights into human bronchial proteomics – how are we progressing and what is next? Expert review of proteomics . 2017. doi: 10.1080/14789450.2017.1417847. PMID: 29260600.

• Huang SJ, Xu YM, Lau ATY. Electronic cigarette: A recent update of its toxic effects on humans. J Cell Physiol. 2017; 233(6):4466-4478. doi: 10.1002/jcp.26352. PMID: 29215738.

• Zheng W, Xu YM, Wu DD, Yao Y, Liang ZL, Tan HW, Lau ATY. Acute and chronic cadmium telluride quantum dots-exposed human bronchial epithelial cells: The effects of particle sizes on their cytotoxicity and carcinogenicity. Biochem Biophys Res Commun. 2017; 495(1):899-903. doi: 10.1016/j.bbrc.2017.11.074. PMID: 29137979.

• Xu YM, Yu FY, Lau ATY. Discovering Epimodifications of the Genome, Transcriptome, Proteome, and Metabolome: the Quest for Conquering the Uncharted Epi(c) Territories. Curr Pharmacol Rep. 2017;3(5):286-93. doi: 10.1007/s40495-017-0103-4.

• Cai NL, Lau ATY, Yu FY, Wu DD, Dai LJ, Mo HY, Lin CM, Xu YM. Purification and characterization of a highly specific polyclonal antibody against human extracellular signal-regulated kinase 8 and its detection in lung cancer. PLoS ONE. 2017; 12(9): e0184755. doi: 10.1371/journal.pone.0184755. PMID: 28902877.

• Lau ATY, Tan HW, Xu YM. Epigenetic Effects of Dietary Trace Elements. Curr Pharmacol Rep. 2017;3(5):232-41. doi: 10.1007/s40495-017-0098-x.

• Wu DD, Lau ATY, Yu FY, Cai NL, Dai LJ, Kim MO, Jin DY, Xu YM. Extracellular signal-regulated kinase 8-mediated NF-kappaB activation increases sensitivity of human lung cancer cells to arsenic trioxide. Oncotarget. 2017. doi: 10.18632/oncotarget.17100. PMID: 28467781.

• Gao Y, Xu Y, Wu D, Yu F, Yang L, Yao Y, Liang Z, Lau ATY. Progressive silencing of the zinc transporter Zip8 (Slc39a8) in chronic cadmium-exposed lung epithelial cells. Acta biochimica et biophysica Sinica. 2017:1-6. doi: 10.1093/abbs/gmx022. PMID: 28338971.

• Xu YM, Gao YM, Wu DD, Yu FY, Zang ZS, Yang L, Yao Y, Cai NL, Zhou Y, Chiu JF, Ching YP, Lau ATY. Aberrant cytokine secretion and zinc uptake in chronic cadmium-exposed lung epithelial cells. Proteomics Clinical applications. 2016. Epub 2016/11/02. doi: 10.1002/prca.201600059. PMID: 27801555.

• Zhang H, Zhu NX, Huang K, Cai BZ, Zeng Y, Xu YM, Liu Y, Yuan YP, Lin CM. iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration. PLoS One. 2016;11(12):e0167474. doi: 10.1371/journal.pone.0167474. PMID: 27907131.

• Yu FY, Xu Q, Wu DD, Lau ATY, Xu YM. The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers. PLoS One. 2016;11(8):e0159801. doi: 10.1371/journal.pone.0159801. PMID: 27483432.

• Zang ZS, Xu YM, Lau ATY. Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8). Toxicol Res. 2016, 5(4): 987-1002. doi: 10.1039/c5tx00424a. PMID: 30090406.

• Xu L, Ge JJ, Huo X, Zhang YL, Lau ATY, Xu XJ. Differential proteomic expression of human placenta and fetal development following e-waste lead and cadmium exposure in utero. Sci Total Environ. 2016 Apr 15;550:1163-70. doi: 10.1016/j.scitotenv.2015.11.084. Epub 2016 Feb 16. PMID: 26895036.

• Xu YM, Wu DD, Zheng W, Yu FY, Yang F, Yao Y, Zhou Y, Ching YP, Lau ATY. Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells. Oncotarget. 2015 Dec 23. doi: 10.18632/oncotarget.6738. [Epub ahead of print] PMID: 26716417.

• Zang ZS, Xu YM, Lau ATY. Preparation of highly specific polyclonal antibody for human zinc transporter ZIP8. Acta Biochim Biophys Sin (Shanghai). 2015 Oct 8. pii: gmv099. Epub 2015 Oct 8. PMID: 26452373.

• Chen DJ, Xu YM, Zheng W, Huang DY, Wong WY, Tai WC, Cho YY, Lau ATY. Proteomic analysis of secreted proteins by human bronchial epithelial cells in response to cadmium toxicity. Proteomics. 2015 Sep;15(17):3075-86. doi: 10.1002/pmic.201400489. Epub 2015 Jun 5. PMID: 25950996.

• Xu YM, Du JY, Lau ATY. Posttranslational modifications of human histone H3: an update. Proteomics. 2014 Sep;14(17-18):2047-60. doi: 10.1002/pmic.201300435. Epub 2014 Aug 8. Review. PMID: 25044606.

• Chen DJ, Xu YM, Du JY, Huang DY, Lau ATY. Cadmium induces cytotoxicity in human bronchial epithelial cells through upregulation of eIF5A1 and NF-kappaB. Biochem Biophys Res Commun. 2014 Feb 28;445(1):95-9. doi: 10.1016/j.bbrc.2014.01.146. Epub 2014 Jan 31. PMID: 24491565.

• Xu YM, Zhou Y, Chen DJ, Huang DY, Chiu JF, Lau ATY. Proteomic Analysis of Cadmium Exposure in Cultured Lung Epithelial Cells: Evidence for Oxidative Stress-Induced Cytotoxicity. Toxicol Res. 2013 2: 280-7. doi: 10.1039/c3tx50014d.

• Xu YM, Huang DY, Chiu JF, Lau ATY. Post-translational modification of human heat shock factors and their functions: a recent update by proteomic approach. J Proteome Res. 2012 May 4;11(5):2625-34. doi: 10.1021/pr201151a. Epub 2012 Apr 24. Review. PMID: 22494029.

• Wang LF, Wang F, Li JT, Wen WH, Zhao J, Jia LT, Meng YL, Cao YX, Yao LB, Chen SY, Xu YM, Yang AG. Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome C. PLoS One. 2012;7(7):e40639. doi: 10.1371/journal.pone.0040639. Epub 2012 Jul 19. PMID: 22829880; PMCID: PMC3400674.

• Zhang J, Zhu F, Li X, Dong Z, Xu Y, Peng C, Li S, Cho YY, Yao K, Zykova TA, Bode AM, Dong Z. Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation. Oncogene. 2012 Apr 5;31(14):1835-44. doi: 10.1038/onc.2011.369. Epub 2011 Aug 22. PMID: 21860413.

• Ren JL, Meng YL, Hu B, Jia LT, Zhang R, Xu YM, Xie QS, Zhang YQ, Jin BQ, Chen SY, Wang T, Yang AG. The effect of direct translocation across endosomes on the cytotoxicity of the recombinant protein e23sFv-Fdt-casp6 to HER2 positive gastric cancer cells. Biomaterials. 2011 Oct;32(30):7641-50. doi: 10.1016/j.biomaterials.2011.06.071. Epub 2011 Jul 20. PMID: 21767874.

• Lau ATY, Lee SY, Xu YM, Zheng D, Cho YY, Zhu F, Kim HG, Li SQ, Zhang Z, Bode AM, Dong Z. Phosphorylation of histone H2B serine 32 is linked to cell transformation. J Biol Chem. 2011 Jul 29;286(30):26628-37. doi: 10.1074/jbc.M110.215590. Epub 2011 Jun 6. PMID: 21646345; PMCID: PMC3143627.

• Peng C, Cho YY, Zhu F, Zhang J, Wen W, Xu Y, Yao K, Ma WY, Bode AM, Dong Z. Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability. J Biol Chem. 2011 Mar 4;286(9):6946-54. doi: 10.1074/jbc.M110.172338. Epub 2010 Dec 23. PMID: 21183680; PMCID: PMC3044950.

• Zhu F, Zykova TA, Peng C, Zhang J, Cho YY, Zheng D, Yao K, Ma WY, Lau ATY, Bode AM, Dong Z. Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation. Cancer Res. 2011 Jan 15;71(2):393-403. doi: 10.1158/0008-5472.CAN-10-2012. Epub 2011 Jan 11. PMID: 21224359.

• Lee SY, Lau ATY, Jeong CH, Shim JH, Kim HG, Kim J, Bode AM, Dong Z. Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation. J Biol Chem. 2010 Sep 17;285(38):29525-34. doi: 10.1074/jbc.M110.127233. Epub 2010 Jul 16. PMID: 20639511; PMCID: PMC2937984.

• Peng C, Cho YY, Zhu F, Xu YM, Wen W, Ma WY, Bode AM, Dong Z. RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway. FASEB J. 2010 Sep;24(9):3490-9. doi: 10.1096/fj.09-151290. Epub 2010 Apr 12. PMID: 20385620; PMCID: PMC2923348.

• Huang HY, Jiang ZF, Li QX, Liu JY, Wang T, Zhang R, Zhao J, Xu YM, Bao W, Zhang Y, Jia LT, Yang AG. Inhibition of human breast cancer cell invasion by siRNA against urokinase-type plasminogen activator.Cancer Invest. 2010 Aug;28(7):689-97. doi: 10.3109/07357901003735642. PMID: 20636107.

• Xu YM, Zhu F, Cho YY, Carper A, Peng C, Zheng D, Yao K, Lau ATY, Zykova TA, Kim HG, Bode AM, Dong Z. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. Cancer Res. 2010 Apr 15;70(8):3218-27. doi: 10.1158/0008-5472.CAN-09-4306. PMID: 20395206.

• Wang F, Ren J, Qiu XC, Wang LF, Zhu Q, Zhang YQ, Huan Y, Meng YL, Yao LB, Chen SY, Xu YM, Yang AG. Selective cytotoxicity to HER2-positive tumor cells by a recombinant e23sFv-TD-tBID protein containing a furin cleavage sequence. Clin Cancer Res. 2010 Apr 15;16(8):2284-94. doi: 10.1158/1078-0432.CCR-09-2367. Epub 2010 Apr 6. PMID: 20371697.

• Zhang DX, Zhao PT, Xia L, Liu LL, Liang J, Zhai HH, Zhang HB, Guo XG, Wu KC, Xu YM, Jia LT, Yang AG, Chen SY, Fan DM. Potent inhibition of human gastric cancer by HER2-directed induction of apoptosis with anti-HER2 antibody and caspase-3 fusion protein. Gut. 2010 Mar;59(3):292-9. doi: 10.1136/gut.2008.155226. Epub 2009 Nov 30. PMID: 19951902.

• Lau ATY, Chiu JF. Biomarkers of lung-related diseases: current knowledge by proteomic approaches. J Cell Physiol. 2009 Dec;221(3):535-43. doi: 10.1002/jcp.21893. Review. PMID: 19681054.

• Wang LF, Zhou Y, Xu YM, Qiu XC, Zhou BG, Wang F, Long H, Chen X, Yang TT, Ma BA, Fan QY, Yang AG. A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma. Cancer Invest. 2009 Aug;27(7):774-80. doi: 10.1080/07357900802427935. PMID: 19488908.

• Ren XL, Xu YM, Bao W, Fu HJ, Wu CG, Zhao Y, Li ZK, Zhang J, Li SQ, Chen WQ, Wang T, Zhang R, Zhang LH, Qian GS, Chen SY, Jia LT, Yang AG. Inhibition of non-small cell lung cancer cell proliferation and tumor growth by vector-based small interfering RNAs targeting HER2/neu. Cancer Lett. 2009 Aug 28;281(2):134-43. doi: 10.1016/j.canlet.2009.02.036. Epub 2009 Mar 31. PMID: 19339104.

• Zhu Q, Xu YM, Wang LF, Zhang Y, Wang F, Zhao J, Jia LT, Zhang WG, Yang AG. Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG2 cells. Cancer Biol Ther. 2009 May;8(9):792-8. Epub 2009 May 8. PMID: 19270509.

• Lei XY, Xu YM, Wang T, Xie QS, Jia LT, Wang LF, Jin BQ, Yan Z, Yao LB, Yang AG. Knockdown of human bid gene expression enhances survival of CD8+ T cells. Immunol Lett. 2009 Jan 29;122(1):30-6. doi: 10.1016/j.imlet.2008.10.009. Epub 2008 Nov 29. PMID: 19046991.

• Shan LQ, Qiu XC, Xu YM, Ji ZG, Yang TT, Chen X, Ma BA, Zhou Y, Fan QY, Yang AG. scFv-mediated delivery of truncated BID suppresses HER2-positive osteosarcoma growth and metastasis. Cancer Biol Ther. 2008 Nov;7(11):1717-22. Epub 2008 Nov 4. PMID: 18787415.

• Zheng D, Cho YY, Lau ATY, Zhang J, Ma WY, Bode AM, Dong Z. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. Cancer Res. 2008 Sep 15;68(18):7650-60. doi: 10.1158/0008-5472.CAN-08-1137. PMID: 18794154; PMCID: PMC2768358.

• Qiu XC, Xu YM, Wang F, Fan QY, Wang LF, Ma BA, Jia LT, Zhao J, Meng YL, Yao LB, Chen SY, Yang AG. Single-chain antibody/activated BID chimeric protein effectively suppresses HER2-positive tumor growth. Mol Cancer Ther. 2008 Jul;7(7):1890-9. doi: 10.1158/1535-7163.MCT-07-2235. PMID: 18644999.

• Lau ATY, Wang Y, Chiu JF. Reactive oxygen species: current knowledge and applications in cancer research and therapeutic. J Cell Biochem. 2008 May 15;104(2):657-67. doi: 10.1002/jcb.21655. Review. PMID: 18172854.

• Lau ATY, Chiu JF. The possible role of cytokeratin 8 in cadmium-induced adaptation and carcinogenesis.Cancer Res. 2007 Mar 1;67(5):2107-13. PMID: 17332340.

• Lau ATY, Zhang J, Chiu JF. Acquired tolerance in cadmium-adapted lung epithelial cells: roles of the c-Jun N-terminal kinase signaling pathway and basal level of metallothionein. Toxicol Appl Pharmacol. 2006 Aug 15;215(1):1-8. Epub 2006 Mar 6. PMID: 16516943.

• Li QX, Zhao J, Liu JY, Jia LT, Huang HY, Xu YM, Zhang Y, Zhang R, Wang CJ, Yao LB, Chen SY, Yang AG. Survivin stable knockdown by siRNA inhibits tumor cell growth and angiogenesis in breast and cervical cancers. Cancer Biol Ther. 2006 Jul;5(7):860-6. Epub 2006 Jul 9. PMID: 16861916.

• Lau ATY, Chiu JF. Proteomic and biochemical analyses of in vitro carcinogen-induced lung cell transformation: synergism between arsenic and benzo[a]pyrene. Proteomics. 2006 Mar;6(5):1619-30. PMID: 16456883.

• Yu CJ, Jia LT, Meng YL, Zhao J, Zhang Y, Qiu XC, Xu YM, Wen WH, Yao LB, Fan DM, Jin BQ, Chen SY, Yang AG. Selective proapoptotic activity of a secreted recombinant antibody/AIF fusion protein in carcinomas overexpressing HER2. Gene Ther. 2006 Feb;13(4):313-20. PMID: 16267568.

• Lau ATY, He QY, Chiu JF. A proteome analysis of the arsenite response in cultured lung cells: evidence for in vitro oxidative stress-induced apoptosis. Biochem J. 2004 Sep 1;382(Pt 2):641-50. PMID: 15175009; PMCID: PMC1133821.

• Xu YM, Wang LF, Jia LT, Qiu XC, Zhao J, Yu CJ, Zhang R, Zhu F, Wang CJ, Jin BQ, Chen SY, Yang AG. A caspase-6 and anti-human epidermal growth factor receptor-2 (HER2) antibody chimeric molecule suppresses the growth of HER2-overexpressing tumors. J Immunol. 2004 Jul 1;173(1):61-7. PMID: 15210759.

• Zhao J, Zhang LH, Jia LT, Zhang L, Xu YM, Wang Z, Yu CJ, Peng WD, Wen WH, Wang CJ, Chen SY, Yang AG. Secreted antibody/granzyme B fusion protein stimulates selective killing of HER2-overexpressing tumor cells. J Biol Chem. 2004 May 14;279(20):21343-8. Epub 2004 Mar 5. PMID: 15004021.

• Lau ATY, Li M, Xie R, He QY, Chiu JF. Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells. Carcinogenesis. 2004 Jan;25(1):21-8. Epub 2003 Sep 26. PMID: 14514659.

• Lau ATY, He QY, Chiu JF. Proteomic technology and its biomedical applications. Acta Biochim Biophys Sin (Shanghai). 2003 Nov;35(11):965-75. Review. PMID: 14614532.

• Jia LT, Zhang LH, Yu CJ, Zhao J, Xu YM, Gui JH, Jin M, Ji ZL, Wen WH, Wang CJ, Chen SY, Yang AG. Specific tumoricidal activity of a secreted proapoptotic protein consisting of HER2 antibody and constitutively active caspase-3. Cancer Res. 2003 Jun 15;63(12):3257-62. PMID: 12810656.

• Lau ATY, Wong WK. Purification and characterization of a major secretory cellobiase, Cba2, from Cellulomonas biazotea. Protein Expr Purif. 2001 Oct;23(1):159-66. PMID: 11570858.

 

BOOKS:

• Xu YM, Yao Y, Lau ATY. Histone H3. In: Choi S, editor. Encyclopedia of Signaling Molecules. New York, NY: Springer New York; 2016. p. 1-6.

• Lau ATY, Xu YM , Chiu JF (2010) Section 3: Perspectives in Human Stem Cell Techniques. Chapter 21. Proteomic Analysis of Human Pluripotent Cells. Human Stem Cell Technology and Biology: A Research Guide and Laboratory Manual, Wiley, Pub. Date: Nov 30, 2010.

• 许彦鸣，药立波主编. 医学分子生物学实验指导(ISBN：9787117073974). 人民卫生出版社, 2006.

 

PATENTS:

• 杨安钢，裘秀春，许彦鸣，贾林涛，于翠娟，赵晶，张立红，王立锋，孟艳玲，王智，范清宇，王成济. 免疫tBid基因及其编码的蛋白和应用. 专利号：ZL.200410026316.4；

• 杨安钢，刘家云，李庆霞，马龙洋，黄红艳，许彦鸣，温伟红，贾林涛，孟艳玲，王成济. 发明名称：HBV特异性干涉靶位点基因及其siRNA和其在抗HBV感染中的应用. 专利号：ZL 200510096347.1。