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Publications

Selected Publications:

publications

• Xu YM, Yu FY, Lau AT. Discovering Epimodifications of the Genome, Transcriptome, Proteome, and Metabolome: the Quest for Conquering the Uncharted Epi(c) Territories. Current Pharmacology Reports. 2017. doi: 10.1007/s40495-017-0103-4.

• Cai NL, Lau AT, Yu FY, Wu DD, Dai LJ, Mo HY, Lin CM, Xu YM. Purification and characterization of a highly specific polyclonal antibody against human extracellular signal-regulated kinase 8 and its detection in lung cancer. PLoS ONE. 2017; 12(9): e0184755. doi: 10.1371/journal.pone.0184755.

• Lau AT, Tan HW, Xu YM. Epigenetic Effects of Dietary Trace Elements. Current Pharmacology Reports. 2017. doi: 10.1007/s40495-017-0098-x.

• Wu DD, Lau ATY, Yu FY, Cai NL, Dai LJ, Kim MO, Jin DY, Xu YM. Extracellular signal-regulated kinase 8-mediated NF-kappaB activation increases sensitivity of human lung cancer cells to arsenic trioxide. Oncotarget. 2017. doi: 10.18632/oncotarget.17100. PubMed PMID: 28467781.

• Gao Y, Xu Y, Wu D, Yu F, Yang L, Yao Y, Liang Z, Lau AT. Progressive silencing of the zinc transporter Zip8 (Slc39a8) in chronic cadmium-exposed lung epithelial cells. Acta biochimica et biophysica Sinica. 2017:1-6. doi: 10.1093/abbs/gmx022. PubMed PMID: 28338971.

• Xu YM, Gao YM, Wu DD, Yu FY, Zang ZS, Yang L, Yao Y, Cai NL, Zhou Y, Chiu JF, Ching YP, Lau AT. Aberrant cytokine secretion and zinc uptake in chronic cadmium-exposed lung epithelial cells. Proteomics Clinical applications. 2016. Epub 2016/11/02. doi: 10.1002/prca.201600059. PubMed PMID: 27801555.

• Zhang H, Zhu NX, Huang K, Cai BZ, Zeng Y, Xu YM, Liu Y, Yuan YP, Lin CM. iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration. PLoS One. 2016;11(12):e0167474. doi: 10.1371/journal.pone.0167474. PubMed PMID: 27907131.

• Yu FY, Xu Q, Wu DD, Lau AT, Xu YM. The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers. PLoS One. 2016;11(8):e0159801. doi: 10.1371/journal.pone.0159801. PubMed PMID: 27483432.

• Zang ZS, Xu YM, Lau AT. Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8). Toxicology Research. 2016, 5(4): 987-1002.

• Xu L, Ge JJ, Huo X, Zhang YL, Lau AT, Xu XJ. Differential proteomic expression of human placenta and fetal development following e-waste lead and cadmium exposure in utero. Science of The Total Environment. 2016 Apr 15;550:1163-70. doi: 10.1016/j.scitotenv.2015.11.084. Epub 2016 Feb 16. PubMed PMID: 26895036.

• Xu YM, Wu DD, Zheng W, Yu FY, Yang F, Yao Y, Zhou Y, Ching YP, Lau AT. Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells. Oncotarget. 2015 Dec 23. doi: 10.18632/oncotarget.6738. [Epub ahead of print] PubMed PMID: 26716417.

• Zang ZS, Xu YM, Lau AT. Preparation of highly specific polyclonal antibody for human zinc transporter ZIP8. Acta Biochim Biophys Sin (Shanghai). 2015 Oct 8. pii: gmv099. Epub 2015 Oct 8. PubMed PMID: 26452373.

• Chen DJ, Xu YM, Zheng W, Huang DY, Wong WY, Tai WC, Cho YY, Lau AT. Proteomic analysis of secreted proteins by human bronchial epithelial cells in response to cadmium toxicity. Proteomics. 2015 Sep;15(17):3075-86. doi: 10.1002/pmic.201400489. Epub 2015 Jun 5. PubMed PMID: 25950996.

• Xu YM, Du JY, Lau AT. Posttranslational modifications of human histone H3: an update. Proteomics. 2014 Sep;14(17-18):2047-60. doi: 10.1002/pmic.201300435. Epub 2014 Aug 8. Review. PubMed PMID: 25044606.

• Chen DJ, Xu YM, Du JY, Huang DY, Lau AT. Cadmium induces cytotoxicity in human bronchial epithelial cells through upregulation of eIF5A1 and NF-kappaB. Biochem Biophys Res Commun. 2014 Feb 28;445(1):95-9. doi: 10.1016/j.bbrc.2014.01.146. Epub 2014 Jan 31. PubMed PMID: 24491565.

• Xu YM, Zhou Y, Chen DJ, Huang DY, Chiu JF, Lau AT. Proteomic Analysis of Cadmium Exposure in Cultured Lung Epithelial Cells: Evidence for Oxidative Stress-Induced Cytotoxicity. Toxicol Res. 2013 2: 280-7. doi: 10.1039/c3tx50014d.

• Xu YM, Huang DY, Chiu JF, Lau AT. Post-translational modification of human heat shock factors and their functions: a recent update by proteomic approach. J Proteome Res. 2012 May 4;11(5):2625-34. doi: 10.1021/pr201151a. Epub 2012 Apr 24. Review. PubMed PMID: 22494029.

• Wang LF, Wang F, Li JT, Wen WH, Zhao J, Jia LT, Meng YL, Cao YX, Yao LB, Chen SY, Xu YM, Yang AG. Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome C. PLoS One. 2012;7(7):e40639. doi: 10.1371/journal.pone.0040639. Epub 2012 Jul 19. PubMed PMID: 22829880; PubMed Central PMCID: PMC3400674.

• Zhang J, Zhu F, Li X, Dong Z, Xu Y, Peng C, Li S, Cho YY, Yao K, Zykova TA, Bode AM, Dong Z. Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation. Oncogene. 2012 Apr 5;31(14):1835-44. doi: 10.1038/onc.2011.369. Epub 2011 Aug 22. PubMed PMID: 21860413.

• Ren JL, Meng YL, Hu B, Jia LT, Zhang R, Xu YM, Xie QS, Zhang YQ, Jin BQ, Chen SY, Wang T, Yang AG. The effect of direct translocation across endosomes on the cytotoxicity of the recombinant protein e23sFv-Fdt-casp6 to HER2 positive gastric cancer cells. Biomaterials. 2011 Oct;32(30):7641-50. doi: 10.1016/j.biomaterials.2011.06.071. Epub 2011 Jul 20. PubMed PMID: 21767874.

• Lau AT, Lee SY, Xu YM, Zheng D, Cho YY, Zhu F, Kim HG, Li SQ, Zhang Z, Bode AM, Dong Z. Phosphorylation of histone H2B serine 32 is linked to cell transformation. J Biol Chem. 2011 Jul 29;286(30):26628-37. doi: 10.1074/jbc.M110.215590. Epub 2011 Jun 6. PubMed PMID: 21646345; PubMed Central PMCID: PMC3143627.

• Peng C, Cho YY, Zhu F, Zhang J, Wen W, Xu Y, Yao K, Ma WY, Bode AM, Dong Z. Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability. J Biol Chem. 2011 Mar 4;286(9):6946-54. doi: 10.1074/jbc.M110.172338. Epub 2010 Dec 23. PubMed PMID: 21183680; PubMed Central PMCID: PMC3044950.

• Zhu F, Zykova TA, Peng C, Zhang J, Cho YY, Zheng D, Yao K, Ma WY, Lau AT, Bode AM, Dong Z. Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation. Cancer Res. 2011 Jan 15;71(2):393-403. doi: 10.1158/0008-5472.CAN-10-2012. Epub 2011 Jan 11. PubMed PMID: 21224359.

• Lee SY, Lau AT, Jeong CH, Shim JH, Kim HG, Kim J, Bode AM, Dong Z. Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation. J Biol Chem. 2010 Sep 17;285(38):29525-34. doi: 10.1074/jbc.M110.127233. Epub 2010 Jul 16. PubMed PMID: 20639511; PubMed Central PMCID: PMC2937984.

• Peng C, Cho YY, Zhu F, Xu YM, Wen W, Ma WY, Bode AM, Dong Z. RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway. FASEB J. 2010 Sep;24(9):3490-9. doi: 10.1096/fj.09-151290. Epub 2010 Apr 12. PubMed PMID: 20385620; PubMed Central PMCID: PMC2923348.

• Huang HY, Jiang ZF, Li QX, Liu JY, Wang T, Zhang R, Zhao J, Xu YM, Bao W, Zhang Y, Jia LT, Yang AG. Inhibition of human breast cancer cell invasion by siRNA against urokinase-type plasminogen activator.Cancer Invest. 2010 Aug;28(7):689-97. doi: 10.3109/07357901003735642. PubMed PMID: 20636107.

• Xu YM, Zhu F, Cho YY, Carper A, Peng C, Zheng D, Yao K, Lau AT, Zykova TA, Kim HG, Bode AM, Dong Z. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. Cancer Res. 2010 Apr 15;70(8):3218-27. doi: 10.1158/0008-5472.CAN-09-4306. PubMed PMID: 20395206.

• Wang F, Ren J, Qiu XC, Wang LF, Zhu Q, Zhang YQ, Huan Y, Meng YL, Yao LB, Chen SY, Xu YM, Yang AG. Selective cytotoxicity to HER2-positive tumor cells by a recombinant e23sFv-TD-tBID protein containing a furin cleavage sequence. Clin Cancer Res. 2010 Apr 15;16(8):2284-94. doi: 10.1158/1078-0432.CCR-09-2367. Epub 2010 Apr 6. PubMed PMID: 20371697.

• Zhang DX, Zhao PT, Xia L, Liu LL, Liang J, Zhai HH, Zhang HB, Guo XG, Wu KC, Xu YM, Jia LT, Yang AG, Chen SY, Fan DM. Potent inhibition of human gastric cancer by HER2-directed induction of apoptosis with anti-HER2 antibody and caspase-3 fusion protein. Gut. 2010 Mar;59(3):292-9. doi: 10.1136/gut.2008.155226. Epub 2009 Nov 30. PubMed PMID: 19951902.

• Lau AT, Chiu JF. Biomarkers of lung-related diseases: current knowledge by proteomic approaches. J Cell Physiol. 2009 Dec;221(3):535-43. doi: 10.1002/jcp.21893. Review. PubMed PMID: 19681054.

• Wang LF, Zhou Y, Xu YM, Qiu XC, Zhou BG, Wang F, Long H, Chen X, Yang TT, Ma BA, Fan QY, Yang AG. A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma. Cancer Invest. 2009 Aug;27(7):774-80. doi: 10.1080/07357900802427935. PubMed PMID: 19488908.

• Ren XL, Xu YM, Bao W, Fu HJ, Wu CG, Zhao Y, Li ZK, Zhang J, Li SQ, Chen WQ, Wang T, Zhang R, Zhang LH, Qian GS, Chen SY, Jia LT, Yang AG. Inhibition of non-small cell lung cancer cell proliferation and tumor growth by vector-based small interfering RNAs targeting HER2/neu. Cancer Lett. 2009 Aug 28;281(2):134-43. doi: 10.1016/j.canlet.2009.02.036. Epub 2009 Mar 31. PubMed PMID: 19339104.

• Zhu Q, Xu YM, Wang LF, Zhang Y, Wang F, Zhao J, Jia LT, Zhang WG, Yang AG. Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG2 cells. Cancer Biol Ther. 2009 May;8(9):792-8. Epub 2009 May 8. PubMed PMID: 19270509.

• Lei XY, Xu YM, Wang T, Xie QS, Jia LT, Wang LF, Jin BQ, Yan Z, Yao LB, Yang AG. Knockdown of human bid gene expression enhances survival of CD8+ T cells. Immunol Lett. 2009 Jan 29;122(1):30-6. doi: 10.1016/j.imlet.2008.10.009. Epub 2008 Nov 29. PubMed PMID: 19046991.

• Shan LQ, Qiu XC, Xu YM, Ji ZG, Yang TT, Chen X, Ma BA, Zhou Y, Fan QY, Yang AG. scFv-mediated delivery of truncated BID suppresses HER2-positive osteosarcoma growth and metastasis. Cancer Biol Ther. 2008 Nov;7(11):1717-22. Epub 2008 Nov 4. PubMed PMID: 18787415.

• Zheng D, Cho YY, Lau AT, Zhang J, Ma WY, Bode AM, Dong Z. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. Cancer Res. 2008 Sep 15;68(18):7650-60. doi: 10.1158/0008-5472.CAN-08-1137. PubMed PMID: 18794154; PubMed Central PMCID: PMC2768358.

• Qiu XC, Xu YM, Wang F, Fan QY, Wang LF, Ma BA, Jia LT, Zhao J, Meng YL, Yao LB, Chen SY, Yang AG. Single-chain antibody/activated BID chimeric protein effectively suppresses HER2-positive tumor growth. Mol Cancer Ther. 2008 Jul;7(7):1890-9. doi: 10.1158/1535-7163.MCT-07-2235. PubMed PMID: 18644999.

• Lau AT, Wang Y, Chiu JF. Reactive oxygen species: current knowledge and applications in cancer research and therapeutic. J Cell Biochem. 2008 May 15;104(2):657-67. doi: 10.1002/jcb.21655. Review. PubMed PMID: 18172854.

• Lau AT, Chiu JF. The possible role of cytokeratin 8 in cadmium-induced adaptation and carcinogenesis.Cancer Res. 2007 Mar 1;67(5):2107-13. PubMed PMID: 17332340.

• Lau AT, Zhang J, Chiu JF. Acquired tolerance in cadmium-adapted lung epithelial cells: roles of the c-Jun N-terminal kinase signaling pathway and basal level of metallothionein. Toxicol Appl Pharmacol. 2006 Aug 15;215(1):1-8. Epub 2006 Mar 6. PubMed PMID: 16516943.

• Li QX, Zhao J, Liu JY, Jia LT, Huang HY, Xu YM, Zhang Y, Zhang R, Wang CJ, Yao LB, Chen SY, Yang AG. Survivin stable knockdown by siRNA inhibits tumor cell growth and angiogenesis in breast and cervical cancers. Cancer Biol Ther. 2006 Jul;5(7):860-6. Epub 2006 Jul 9. PubMed PMID: 16861916.

• Lau AT, Chiu JF. Proteomic and biochemical analyses of in vitro carcinogen-induced lung cell transformation: synergism between arsenic and benzo[a]pyrene. Proteomics. 2006 Mar;6(5):1619-30. PubMed PMID: 16456883.

• Yu CJ, Jia LT, Meng YL, Zhao J, Zhang Y, Qiu XC, Xu YM, Wen WH, Yao LB, Fan DM, Jin BQ, Chen SY, Yang AG. Selective proapoptotic activity of a secreted recombinant antibody/AIF fusion protein in carcinomas overexpressing HER2. Gene Ther. 2006 Feb;13(4):313-20. PubMed PMID: 16267568.

• Lau AT, He QY, Chiu JF. A proteome analysis of the arsenite response in cultured lung cells: evidence for in vitro oxidative stress-induced apoptosis. Biochem J. 2004 Sep 1;382(Pt 2):641-50. PubMed PMID: 15175009; PubMed Central PMCID: PMC1133821.

• Xu YM, Wang LF, Jia LT, Qiu XC, Zhao J, Yu CJ, Zhang R, Zhu F, Wang CJ, Jin BQ, Chen SY, Yang AG. A caspase-6 and anti-human epidermal growth factor receptor-2 (HER2) antibody chimeric molecule suppresses the growth of HER2-overexpressing tumors. J Immunol. 2004 Jul 1;173(1):61-7. PubMed PMID: 15210759.

• Zhao J, Zhang LH, Jia LT, Zhang L, Xu YM, Wang Z, Yu CJ, Peng WD, Wen WH, Wang CJ, Chen SY, Yang AG. Secreted antibody/granzyme B fusion protein stimulates selective killing of HER2-overexpressing tumor cells. J Biol Chem. 2004 May 14;279(20):21343-8. Epub 2004 Mar 5. PubMed PMID: 15004021.

• Lau AT, Li M, Xie R, He QY, Chiu JF. Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells. Carcinogenesis. 2004 Jan;25(1):21-8. Epub 2003 Sep 26. PubMed PMID: 14514659.

• Lau AT, He QY, Chiu JF. Proteomic technology and its biomedical applications. Acta Biochim Biophys Sin (Shanghai). 2003 Nov;35(11):965-75. Review. PubMed PMID: 14614532.

• Jia LT, Zhang LH, Yu CJ, Zhao J, Xu YM, Gui JH, Jin M, Ji ZL, Wen WH, Wang CJ, Chen SY, Yang AG. Specific tumoricidal activity of a secreted proapoptotic protein consisting of HER2 antibody and constitutively active caspase-3. Cancer Res. 2003 Jun 15;63(12):3257-62. PubMed PMID: 12810656.

• Lau AT, Wong WK. Purification and characterization of a major secretory cellobiase, Cba2, from Cellulomonas biazotea. Protein Expr Purif. 2001 Oct;23(1):159-66. PubMed PMID: 11570858.

 

BOOKS:

• Xu YM, Yao Y, Lau AT. Histone H3. In: Choi S, editor. Encyclopedia of Signaling Molecules. New York, NY: Springer New York; 2016. p. 1-6.

• Lau AT, Xu YM , Chiu JF (2010) Section 3: Perspectives in Human Stem Cell Techniques. Chapter 21. Proteomic Analysis of Human Pluripotent Cells. Human Stem Cell Technology and Biology: A Research Guide and Laboratory Manual, Wiley, Pub. Date: Nov 30, 2010.

• 许彦鸣,药立波主编. 医学分子生物学实验指导(ISBN:9787117073974). 人民卫生出版社, 2006.

 

PATENTS:

• 杨安钢,裘秀春,许彦鸣,贾林涛,于翠娟,赵晶,张立红,王立锋,孟艳玲,王智,范清宇,王成济. 免疫tBid基因及其编码的蛋白和应用. 专利号:ZL.200410026316.4;

• 杨安钢,刘家云,李庆霞,马龙洋,黄红艳, 许彦鸣,温伟红,贾林涛,孟艳玲,王成济. 发明名称:HBV特异性干涉靶位点基因及其siRNA和其在抗HBV感染中的应用. 专利号:ZL 200510096347.1。